The cell cycle is governed by a network of surveillance mechanisms that detect DNA lesions and coordinate repair with progression through G1, S, G2 and M phases. Central to this system are sensor ...
Researchers in the lab of Jean Cook, Ph.D., chair and professor in the Department of Biochemistry and Biophysics, have identified the cellular processes that occur when you take a cancer drug meant to ...
Many cancer-driving mutations disable a key checkpoint in the cell’s cycle between growth and division, resulting in unchecked activity of the E2F family of transcription factor proteins. A set of ...
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