The US Food and Drug Administration (FDA) has revised a 2023 draft guidance on master protocols for drug and biological ...

Researchers used real-world clinical data to attempt to emulate a randomized controlled trial testing the effectiveness of two blood thinners, apixaban and warfarin, to prevent stroke in patients with ...

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

A new randomized clinical trial from investigators at Mass General Brigham’s Neuroscience Institute and Department of ...

In the 1940s, medical researchers began using randomized controlled trials to assess the efficacy of health interventions. In RCTs, researchers create randomly assigned treatment and control groups, ...

A new randomized clinical trial from investigators at Mass General Brigham's Neuroscience Institute and Department of ...

In this multicenter, open-label, randomized, controlled trial in China, we assigned participants with newly diagnosed Kawasaki disease in a 1:1 ratio to receive prednisolone plus standard treatment or ...