Case Western Reserve scientists have discovered that speed matters when it comes to how messenger RNA (mRNA) deciphers critical information within the genetic code—the complex chain of instructions ...

Alternative genetic decoding can be either a global phenomenon that affects the decoding of most or all mRNAs, or a local recoding that affects particular sites in a few mRNAs. Global alterations in ...

Living things, from bacteria to humans, depend on a workforce of proteins to carry out essential tasks within their cells. Proteins are chains of amino acids that are strung together according to ...

The choice of codons can influence local translation kinetics during protein synthesis. Whether codon preference is linked to cotranslational regulation of polypeptide folding remains unclear. Here, ...

In recent years, messenger RNA, DNA’s close cousin in life’s complex process of going from a string of genetic blueprints to fully functioning organism, has received intense scrutiny in the scientific ...