Unique instruments automate sample preparation, quality control for cryo-electron microscopy

Cryo-electron microscopy (cryo-EM) can help scientists determine the three-dimensional structure of proteins in unprecedented detail. Jacques Dubochet, former group leader at EMBL, shared the 2017 ...
EurekAlert!

An electron microscope breakthrough delivers sharper images of our body’s tiniest proteins

A laser (purple) is powerfully amplified by highly polished mirrors and focused on the electron beam (blue) to shift its phase and increase the cryo-EM microscope’s contrast, allowing biologists to ...
Nature

Making samples one billion times bigger lets simple microscopes pinpoint amino acids

Stretching protein samples in all directions pulls molecules farther apart, allowing them to be visualized using only light ...

Cryo-EM imaging reveals how a molecular gate lets bulky proteins pass cell membranes intact

How large, fully folded proteins can pass through cell membranes without destroying them has long been one of the open questions in cell biology. Using cryo-electron microscopy (cryo-EM), Leonid ...