Long before overt type 1 diabetes, the pancreas is already changing. By profiling more than 10,000 islets and 16 million cells from donors spanning preclinical and clinical stages, Steenbuck, Damond ...
In this issue, Jiang et al. introduce a proteomic method called LoopID and show that JMJD2 demethylases have a non-catalytic role in promoting enhancer–promoter looping in mouse embryonic stem cells.
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